Comparison of the Effects between Growth Hormone and Hyaluronic Acid on Degenerative Cartilage of Knee in Rabbit
Journal of the Korean Academy of Rehabilitation Medicine
;
: 247-252, 2008.
Article
in Korean
| WPRIM
| ID: wpr-723950
ABSTRACT
OBJECTIVE:
To explore whether the growth hormone is effective in the treatment of degenerative cartilage of knee in rabbits.METHOD:
Thirty New Zealand white rabbits were administered intra-articular injection with monosodium iodoacetate (Sigma, St. Louis, USA) 2.5 mg and divided into 3 groups. Each group was administered with hyaluronic acid (Hyruan plus(R), LG life science, Seoul, Korea)(group A) 0.6 ml, growth hormone (Declage(R), LG life science, Seoul, Korea) (group B) or saline (group C) 0.6 ml intra-articulary once a week for 4 weeks, beginning 4 weeks after the degeneration induction. All rabbits were killed 9 weeks after degeneration induction. The histologic morphology was observed by optical microscope with knee cartilage.RESULTS:
Mankin score was 2.4+/-1.3 in group A, 3.9+/-1.7 in group B, 7.4+/-0.8 in group C. Yoshimi score was 1.5+/-0.7 in group A, 2.2+/-0.9 in group B, 4.4+/-0.6 in group C. Gross and microscopic morphologic findings showed that group C represented the more severe than group A & B (p<0.01), also group A was better than group B (p<0.05).CONCLUSION:
Growth hormone is effective on degenerative knee cartilage in rabbit model, but less than the hyaluronic acid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Growth Hormone
/
Cartilage
/
Biological Science Disciplines
/
Hyaluronic Acid
/
Injections, Intra-Articular
/
Knee
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2008
Type:
Article
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