Neurophysiological Changes after Botulinum Toxin A Injection in Normal Adults
Journal of the Korean Academy of Rehabilitation Medicine
;
: 55-60, 2002.
Article
in Korean
| WPRIM
| ID: wpr-724019
ABSTRACT
OBJECTIVE:
To evaluate the neurophysiological changes after intramuscular botulinum toxin A (BTX-A) injection in normal adults.METHOD:
Nine subjects were studied by electrophysiological measurements before and after the injections. BTX-A (5 IU, Botox , Allergen, USA) was injected in the extensor digitorum brevis (EDB) muscles. Thereafter, electrophysiological measurement was followed up during 6 months.RESULTS:
The compound muscle action potential (CMAP) amplitude of injected EDB muscle decreased significantly for 8 weeks, a maximal decrement at 4 weeks after injection. CMAP peak area changes over time were nearly identical to those of CMAP peak amplitudes. The first/fourth amplitude change of CMAP with 3-Hz repetitive nerve stimulation decreased significantly for 8 weeks and the amplitude following post-exercise activation increased significantly after injection. There were no significant changes in F-wave amplitude and latency.CONCLUSION:
Serial electrophysiological measurements after intramuscular BTX-A injection into EDB provide useful information for the neurophysiological change after injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Botulinum Toxins
/
Action Potentials
/
Muscles
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2002
Type:
Article
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