Electrophysiological Changes after Botulinum Toxin Type A in Children with Cerebral Palsy
Journal of the Korean Academy of Rehabilitation Medicine
;
: 179-184, 2010.
Article
in Korean
| WPRIM
| ID: wpr-724311
ABSTRACT
OBJECTIVE:
To investigate the electrophysiological changes after botulinum toxin type A injection in children with cerebral palsy.METHOD:
Sixteen children with spastic cerebral palsy enrolled in the study. Botulinum toxin type A (Dysport(R)) was injected into gastrocnemius muscles. Electrophysiological assessments included the compound motor action potential of the tibial nerve, the sensory nerve action potential of the sural nerve, the H-reflex and the T-reflex before injection, and at 2 weeks and 4 weeks after the injection. Modified Ashworth scale was used to evaluate spasticity before, 2 weeks and 4 weeks after the injection.RESULTS:
Modified Ashworth scale of the ankle decreased at 2 weeks and 4 weeks after injection. The amplitude of the H-reflex and H(max)/M(max) ratio decreased significantly at 4 weeks. The amplitude of the T-reflex decreased at 2 weeks and 4 weeks. The correlation between changes in modified Ashworth scale of the ankle and the changes in electrophysiological parameters at 4 weeks after injection were not significant.CONCLUSION:
The change in T-reflex is faster than the change of H-reflex and H(max)/M(max) ratio after botulinum toxin A injection in children with cerebral palsy. Electrophysiological tests could quantify the change in spasticity after botulinum toxin injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organic Chemicals
/
Sural Nerve
/
Tibial Nerve
/
Botulinum Toxins
/
Action Potentials
/
Cerebral Palsy
/
Botulinum Toxins, Type A
/
H-Reflex
/
Ankle
/
Muscle Spasticity
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2010
Type:
Article
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