The Expression of HOX D3 and Vascular Endothelial Growth Factor-C in Skin Tumors / 대한피부과학회지
Korean Journal of Dermatology
;
: 354-361, 2007.
Article
in Korean
| WPRIM
| ID: wpr-72444
ABSTRACT
BACKGROUND:
The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin alpha v beta3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread.OBJECTIVE:
This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers.METHODS:
The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget's disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas.RESULTS:
Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget's disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05).CONCLUSION:
These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Skin Neoplasms
/
Endothelium, Lymphatic
/
Carcinoma, Basal Cell
/
Carcinoma, Squamous Cell
/
Plasminogen Activators
/
Urokinase-Type Plasminogen Activator
/
Up-Regulation
/
Sensitivity and Specificity
/
Paget Disease, Extramammary
Type of study:
Diagnostic study
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2007
Type:
Article
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