Expression of Protoporphyrin IX Induced by Liposome delta-5-aminolevulinic Acid in Cultured Sebocytes and Hair Organs / 대한피부과학회지
Korean Journal of Dermatology
;
: 327-331, 2007.
Article
in Korean
| WPRIM
| ID: wpr-72449
ABSTRACT
BACKGROUND:
Photodynamic therapy with topical delta-5-aminolevulinic acid (ALA) has been introduced for effective treatment of facial acne. Topical routes for ALA have been explored via a photosensitizer delivery system.OBJECTIVE:
We performed this study to evaluate absorption of liposome ALA (Lipo-ALA) into the sebocytes of cultured sebaceous glands and hair organs.METHODS:
We cultured KGM sebocytes that were derived from human sebaceous glands. In addition, we cultured William E media pilosebaceous hair units that were isolated from the occipital scalp. Lipo-ALA (10 microgram/ml) and ALA (10 microgram/ml) were added to the 1 ml KGM containing sebocytes for 24 hours and the 1 ml William E media containing pilosebaceous hair units for 6, 24, 48 and 72 hours, respectively.RESULTS:
Absorption of Lipo-ALA into the sebocytes of cultured sebaceous gland and hair organs was higher than that of ALA.CONCLUSION:
Lipo-ALA may be considered as an effective photosensitizer in photodynamic therapy for facial acne.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Photochemotherapy
/
Scalp
/
Sebaceous Glands
/
Acne Vulgaris
/
Absorption
/
Hair
/
Liposomes
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2007
Type:
Article
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