Pain Relief Effect of Calcitonin Injection in Ovariectomized Rats
Journal of the Korean Academy of Rehabilitation Medicine
;
: 587-590, 2002.
Article
in Korean
| WPRIM
| ID: wpr-724527
ABSTRACT
OBJECTIVE:
To confirm the effect of calcitonin injection relieving pain in ovariectomized rats.METHOD:
Thirty five Sprague-Dawley rats were randomly divided into five groups (high dose calcitonin group (112 U/ Kg), low dose calcitonin group (56 U/Kg), free calcitonin group, ovariectomy group, control group). To assess the pain in ovariectomized rats, the tail of rats were dived in waters of 50+/-1degrees C. Then the tail withdrawal time was measured (tail withdrawal test). The tail withdrawal test was performed in once a week for eight weeks.RESULTS:
1. At seven and eight weeks after injection, the tail withdrawal time of high and low dose calcitonin group compared with that of ovariectomy group were significantly prolonged (p<0.05). 2. At eight weeks after injection, the tail withdrawal time of free calcitonin group compared with that of ovariectomy group was significantly prolonged (p<0.05).CONCLUSION:
The effect of calcitonin injection relieving pain in ovariectomized rats was found.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tail
/
Calcitonin
/
Water
/
Ovariectomy
/
Control Groups
/
Rats, Sprague-Dawley
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2002
Type:
Article
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