Effects of Transplantation of Human Embryonic Stem Cellson Functional Recovery in Spinal Cord Injured Rats
Journal of the Korean Academy of Rehabilitation Medicine
;
: 491-500, 2008.
Article
in English
| WPRIM
| ID: wpr-724668
ABSTRACT
OBJECTIVE:
To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord.METHOD:
Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5x10(3)/5microliter, 2x10(4)/5microliter). The hES cells were transplanted 1 week after a SCI.RESULTS:
The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter.CONCLUSION:
These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Spinal Cord Injuries
/
New York
/
Cicatrix
/
Rats, Sprague-Dawley
/
Transplants
/
Evoked Potentials, Somatosensory
/
Extremities
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Journal of the Korean Academy of Rehabilitation Medicine
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS