The Clinical Effects of Nicorandil during Percutaneous Coronary Intervention in Patients with Unstable Angina
Korean Circulation Journal
;
: 322-327, 2005.
Article
in Korean
| WPRIM
| ID: wpr-72480
ABSTRACT
BACKGROUND AND OBJECTIVES:
The purpose of the study was to evaluate the clinical effect of Nicorandil during percutaneous coronary intervention (PCI) in patients with unstable angina (UA). SUBJECTS ANDMETHODS:
Two hundred patients (61+/-10 years, male 143) with UA were randomly assigned to two groups intravenous Isosorbide dinitrate (Group I, n=100) and intravenous Nicorandil (Group II, n=100). PCI was performed 12-48 hours after infusion of the agents. The post-procedural cardiac enzymes, 6-month MACE (major adverse cardiac event) and left ventricular ejection fraction (LVEF) were compared between the two groups.RESULTS:
Successful PCI was performed in 96 patients (Group I=54, Group II=42). Patients requiring either emergent coronary angiography, temporary pacemaker or platelet glycoprotein IIb/IIIa receptor blocker were excluded. No significant differences were observed between the two groups in terms of the clinical and coronary angiographic characteristics. The level of creatine kinase-MB was elevated in 9 (17%) and 6 patients (14%), troponin T in 16 (30%) and 6 (14%) and troponin I in 25 (46%) and 9 (21%) patients of Groups I and II, respectively, after the PCI. The elevation of all troponins was lower in Group II (28 vs. 10 patients, p=0.01). MACE developed in 9 (17%) and 5 (12%) patients of Groups I and II (p=NS), respectively, during the 6-month clinical follow-up. The LVEF was higher in Group II than in Group I on follow-up echocardiography (65.4+/-7.2% vs. 71.0+/-6.7%, p=0.003).CONCLUSION:
Nicorandil may have a myocardial protective effect during PCI in patients with UA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stroke Volume
/
Troponin
/
Blood Platelets
/
Echocardiography
/
Glycoproteins
/
Follow-Up Studies
/
Coronary Angiography
/
Nitroglycerin
/
Angioplasty
/
Troponin I
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2005
Type:
Article
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