Polymorphism of CTLA-4 Gene in Patients with Bipolar Disorder
Journal of the Korean Society of Biological Psychiatry
;
: 80-84, 2003.
Article
in Korean
| WPRIM
| ID: wpr-724802
ABSTRACT
OBJECTIVE:
Bipolar disorder is known to have strong genetic background and cellular immune activation. Based on the hypothesis that abnormalities of normal inhibitory control of T cell immunity can contribute to the pathophysiology of bipolar disorder, we investigated the relationship between the first exon at position +49(A/G) polymorphism of cytotoxic T lymphocyte antigen 4(CTLA4) gene and bipolar disorder.METHOD:
Among the Korean patients diagnosed as bipolar disorder according to DSM-IV, 90 patients without serious medical illness, neurologic illness, hormonal disorder, or concomitant mental illness were selected. The normal control group consisted of 149 age-and sex-matched subjects without current or past history of autoimmune diseases or mental disorder. DNA was extracted from whole blood and the exon 1 region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed using single strand conformation polymorphism.RESULTS:
There were no significant differences in genotype frequencies of G/G, G/A, and A/A between the patients with bipolar disorder and the control group(48.9% vs 46.3%, 44.4% vs 39.6%, and 6.7% vs 14.1%, respectively). There were no significant differences in allelic frequencies of G and A between the patients with bipolar disorder and the control group(71.1% vs 66.1%, and 28.9% vs 33.9%, respectively).CONCLUSION:
This study did not show the association of exon 1 polymorphism of CTLA-4 gene with bipolar disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Bipolar Disorder
/
DNA
/
Lymphocytes
/
Polymerase Chain Reaction
/
Exons
/
Diagnostic and Statistical Manual of Mental Disorders
/
Genotype
/
Mental Disorders
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS