Association of Serotonin Transporter Gene Polymorphism with Alcohol Dependence
Journal of the Korean Society of Biological Psychiatry
;
: 159-167, 2003.
Article
in Korean
| WPRIM
| ID: wpr-724828
ABSTRACT
OBJECTIVE:
Under the hypothesis that 5-HTTLPR polymorphism plays some role in the susceptibility or vulnerability of some subgroup of alcohol dependence, associations of 5-HTTLPR polymorphism with alcohol dependence were examined.METHOD:
This association analysis included 109 Korean alcohol dependent and 113 Korean control subjects. DNA of all subjects were genotyped for the biallelic functional polymorphism in the 5-HTTLPR. Considering the likelihood of heterogeneity in the alcohol dependence phenotype, alcohol dependent subjects were subgrouped by onset age, family history of alcohol dependence and severity of withdrawal symptoms.RESULTS:
There were no significant differences in the frequencies of either the 5-HTTLPR genotype or the short vs. long allele in alcohol dependent and control subjects. The frequency of the S allele and S-carrier (LS or SS genotype) was significantly increased in the early onset alcohol dependent subjects and the familial alcohol dependent subjects compared with that in the control subjects.CONCLUSION:
The results suggest that the 5-HTT 'S' promoter polymorphism is associated with an increased susceptibility or vulnerability to develop early onset alcohol dependence and familial alcohol dependence, which characterize Cloninger's type 2 alcohol dependence.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Substance Withdrawal Syndrome
/
Population Characteristics
/
DNA
/
Serotonin
/
Age of Onset
/
Alcoholism
/
Alleles
/
Serotonin Plasma Membrane Transport Proteins
/
Genotype
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2003
Type:
Article
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