Antipsychotics and Abnormality in Glucose Regulation
Journal of the Korean Society of Biological Psychiatry
;
: 107-115, 2003.
Article
in Korean
| WPRIM
| ID: wpr-724835
ABSTRACT
OBJECTIVE:
The purpose of this study was to know about the mechanism of pathogenesis of type 2 diabetes mellitus by using of blood glucose, glucoregulatory factor, insulin resistance in schizophrenic patients receiving antipsychotics.METHOD:
Modified oral glucose tolerance tests were performed in 20 schizophrenic patients receiving haloperidol, risperidone and olanzapine. Insulin, glucagon, C-peptide and cortisol were measured in 0, 15, 45, 75 minutes after glucose loading, and insulin resistance was calculated by HOMA(homeostasis model assessment) method.RESULT:
Olanzapine-treated patients had significant glucose elevation 45 minutes after glucose challenge. Also modest increases in HOMA IR values were detected in patients treated with olanzapine.CONCLUSION:
Olanzapine treatment of non-diabetic patients with schizophrenia can be associated with type 2 diabetes mellitus through the elevation of glucose and insulin resistance. Elevated insulin resistance may be a causative mechanism of type 2 diabetes mellitus in patients receiving olanzapine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Antipsychotic Agents
/
Blood Glucose
/
C-Peptide
/
Insulin Resistance
/
Glucagon
/
Hydrocortisone
/
Risperidone
/
Diabetes Mellitus, Type 2
/
Glucose
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2003
Type:
Article
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