Psychosis in Parkinson
Journal of the Korean Society of Biological Psychiatry
;
: 132-135, 1997.
Article
in Korean
| WPRIM
| ID: wpr-724904
ABSTRACT
Current treatment strategies for levodopa-induced psychosis in advanced Parkinson's disease have had limited success. Reduction or discontinuation of levodopa and coadministration with dopamine-blocking neuroleptics may attenuate the psychotic symptoms, but these strategies are associated with worsening of parkinsonian symptoms. Administration of 5-HT3 receptor antagonist ; ondansetron, a newer strategy to attenuate psychosis of Parkinson' disease without motor deterioration was introduced. A 41-year-old young-onset male, who was diagnosed as Parkinson's disease 7 years ago, was treated with levodopa therapy, and had levodopa-induced psychosis(delusion, hallucination, paranoid, insomnia). After trial of ondansetron, he showed improvement in the Brief Psychiatric Rating Scale(from 21 points to 9 points) in spite of increasing the dosage of levodopa. With ondansetron, we could increase the dosage of levodopa without psychotic complications(esp, hallucination), and he showed improvement in the motor fluctuation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Psychotic Disorders
/
Antipsychotic Agents
/
Levodopa
/
Ondansetron
/
Receptors, Serotonin, 5-HT3
/
Hallucinations
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
1997
Type:
Article
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