Combined Dexamethasone/Insulin-induced Hypoglyeemic Test in Manic and Schizophrenic Patients
Journal of the Korean Society of Biological Psychiatry
;
: 272-278, 1997.
Article
in Korean
| WPRIM
| ID: wpr-724943
ABSTRACT
Many investigators are trying to elucidate the pathogenesis of psychiatric disorders on the basis of neuroendocrine responses to stimulation or perturbation. Dexamethasone(DEX) suppression has been the most widely utilized as the prototypical challenge test. Dexamethasone suppression test(DST) has proven to be valuable in diagnosing the depressive spectrum disorder. Reported specificity of diagnosis of depression is relatively high, but sensitivity is limited. Some researchers used the combination of dexamethasone and corticotropin releasing hormone(CRH) in order to improve the sensitivity. They reported that combined DEX/CRH test, i.e., we administered the insulin instead of CRH. Total subjects were 28(7 normal controls, 10 manic patients, 11 schizophrenic, patients). Subject were token DEX(1.5mg p.o.) at 11 p.m., insulin 16 hours later(0.1 unit/kg i.v.). Five blood samples for the determination of cortisol and ACTH were serially drawn at 15 minute interval. The results are as following 1) The cortisol an ACTH levels of manic subjects increased following insulin administration. Manic subjects showed higher levels of cortisol and ACTH than schizophrenic and normal control subjects. The cortisol and ACTH levels of schizophrenic and normal control subjects did not show gross changes. 2) The sensitivity of the test was lower than that of reported DEX/CRH test.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research Personnel
/
Dexamethasone
/
Hydrocortisone
/
Sensitivity and Specificity
/
Adrenocorticotropic Hormone
/
Depression
/
Diagnosis
/
Insulin
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
1997
Type:
Article
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