Animal Models of Alzheimer's Dementia
Journal of the Korean Society of Biological Psychiatry
;
: 149-152, 1999.
Article
in Korean
| WPRIM
| ID: wpr-724972
ABSTRACT
Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice model were amyloid changes, gliotic changes. A-beta increases, deficit in LTP(ling-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mice, Transgenic
/
Neurofibrillary Tangles
/
Models, Animal
/
Dementia
/
Presenilins
/
Alzheimer Disease
/
Amyloid
/
Neurons
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
1999
Type:
Article
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