Clinical Implications of EEG and ERP as Biological Markers for Alzheimer's Disease and Mild Cognitive Impairment
Journal of the Korean Society of Biological Psychiatry
; : 119-128, 2013.
Article
in Ko
| WPRIM
| ID: wpr-725007
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: Memory impairment is a very important mental health issue for elderly and adults. Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Early detection of the prodromal stage of patients with AD is an important topic of interest for both mental health clinicians and policy makers. METHODS: Electroencephalograpgy (EEG) has been used as a possible biological marker for patients with MCI, and AD. In this review, we will summarize the clinical implications of EEG and ERP as a biological marker for AD and MCI. RESULTS: EEG power density, functional coupling, spectral coherence, synchronization, and connectivity were analyzed and proved their clinical efficacy in patients with the prodromal stage of AD. Serial studies on late event-related potentials (ERPs) were also conducted in MCI patients as well as healthy elders. Even though these EEG and ERP studies have some limitations for their design and method, their clinical implications are increasing rapidly. CONCLUSION: EEG and ERP can be used as biological markers of AD and MCI. Also they can be used as useful tools for early detection of AD and MCI patients. They are useful and sensitive research tools for AD and MCI patients. However, some problems remain to be solved until they can be practical measures in clinical setting.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biomarkers
/
Mental Health
/
Administrative Personnel
/
Electroencephalography
/
Evoked Potentials
/
Alzheimer Disease
/
Cognitive Dysfunction
/
Prodromal Symptoms
/
Memory
/
Methods
Type of study:
Screening_studies
Limits:
Adult
/
Aged
/
Humans
Language:
Ko
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2013
Type:
Article