A Prospective Study on an Association between Apolipoprotein E epsilon4 and Cognitive Change in Community-Dwelling Elders with Alzheimer's Disease
Journal of the Korean Society of Biological Psychiatry
;
: 104-110, 2013.
Article
in Korean
| WPRIM
| ID: wpr-725010
ABSTRACT
OBJECTIVES:
The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) epsilon4 on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD).METHODS:
The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE epsilon4.RESULTS:
The impact of epsilon4 allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033).CONCLUSIONS:
The APOE epsilon4 allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Apolipoproteins E
/
Prospective Studies
/
Alleles
/
Alzheimer Disease
/
Memory, Episodic
/
Memory
Type of study:
Observational study
/
Risk factors
/
Screening study
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2013
Type:
Article
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