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Animal Models of Demyelination and ¹H-Magnetic Resonance Spectroscopy
Journal of the Korean Society of Biological Psychiatry ; : 1-9, 2017.
Article in Korean | WPRIM | ID: wpr-725019
ABSTRACT
The proton magnetic resonance spectroscopy (¹H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathologic Processes / Rodentia / Autoimmune Diseases / Spectrum Analysis / Brain / Choline / Demyelinating Diseases / Aspartic Acid / Glutamic Acid / Butyric Acid Type of study: Prognostic study Limits: Animals / Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathologic Processes / Rodentia / Autoimmune Diseases / Spectrum Analysis / Brain / Choline / Demyelinating Diseases / Aspartic Acid / Glutamic Acid / Butyric Acid Type of study: Prognostic study Limits: Animals / Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2017 Type: Article