Serum Homocysteine Level and MTHFR C677T, A1298C Gene Polymorphism in Korean Schizophrenics
Journal of the Korean Society of Biological Psychiatry
;
: 114-122, 2005.
Article
in Korean
| WPRIM
| ID: wpr-725074
ABSTRACT
OBJECTIVES:
Recently in schizophrenia high incidence of MTHFR(methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics.METHOD:
We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed.RESULTS:
1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level (29.99uM/L) than other group(CT 13.34uM/L, CC 9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia.CONCLUSION:
Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Genetic Variation
/
Incidence
/
Eating
/
Mutation Rate
/
Folic Acid
/
Genotype
/
Homocysteine
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2005
Type:
Article
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