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Serum Homocysteine Level and MTHFR C677T, A1298C Gene Polymorphism in Korean Schizophrenics
Journal of the Korean Society of Biological Psychiatry ; : 114-122, 2005.
Article in Korean | WPRIM | ID: wpr-725074
ABSTRACT

OBJECTIVES:

Recently in schizophrenia high incidence of MTHFR(methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics.

METHOD:

We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed.

RESULTS:

1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level (29.99uM/L) than other group(CT 13.34uM/L, CC 9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia.

CONCLUSION:

Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Genetic Variation / Incidence / Eating / Mutation Rate / Folic Acid / Genotype / Homocysteine Type of study: Incidence study / Prognostic study Limits: Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Genetic Variation / Incidence / Eating / Mutation Rate / Folic Acid / Genotype / Homocysteine Type of study: Incidence study / Prognostic study Limits: Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2005 Type: Article