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No Association between the 5-HT6 Receptor C267T Polymorphism and Response to Citalopram Treatment in Patient with Major Depressive Disorder
Journal of the Korean Society of Biological Psychiatry ; : 262-267, 2007.
Article in Korean | WPRIM | ID: wpr-725084
ABSTRACT
The serotonin 6(5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder(MDD).

METHODS:

Citalopram was administered for 8 weeks to the 90 patients who completed study. 21-item Hamilton depression rating scale(HAMD-21) was used as a outcome measure.

RESULTS:

We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.

CONCLUSIONS:

These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with the treatment response to citalopram.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Citalopram / Serotonin / Outcome Assessment, Health Care / Depression / Depressive Disorder, Major / Alleles / Genotype / Antidepressive Agents Limits: Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Citalopram / Serotonin / Outcome Assessment, Health Care / Depression / Depressive Disorder, Major / Alleles / Genotype / Antidepressive Agents Limits: Humans Language: Korean Journal: Journal of the Korean Society of Biological Psychiatry Year: 2007 Type: Article