P50 and Schizophrenia
Journal of the Korean Society of Biological Psychiatry
; : 137-143, 2006.
Article
in Ko
| WPRIM
| ID: wpr-725167
Responsible library:
WPRO
ABSTRACT
One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.
Key words
Full text:
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Index:
WPRIM
Main subject:
Schizophrenia
/
Evoked Potentials
/
Sensory Gating
/
Endophenotypes
/
Neurons
Language:
Ko
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2006
Type:
Article