Investigation into the Possible Genetic Role of Serotonin and Dopamine Transporters in Psychological Resilience
Journal of the Korean Society of Biological Psychiatry
;
: 16-20, 2018.
Article
in Korean
| WPRIM
| ID: wpr-725229
ABSTRACT
OBJECTIVES:
Psychological resilience is the ability to cope with stress. The genetic background behind psychological resilience is not much known. The serotonin transporter and dopamine transporter are implicated in stress related psychology and emotional processing. The aim of this study is to investigate a possible genetic role of functional polymorphisms of serotonin and dopamine transporters for psychological resilience.METHODS:
A total of 951 healthy adult subjects were included. Psychological resilience was measured using Connor-Davidson Resilience Scale (CD-RISC). Genotyping was performed for serotonin transporter gene (SERT) promoter variable number tandem repeat (VNTR) and dopamine transporter gene (DAT1) 3'-untranslated region (UTR) VNTR. Genetic association analysis was conducted between genotypes and the CD-RISC score.RESULTS:
No genetic association was observed for SERT promoter VNTR or DAT1 3'-UTR VNTR with CD-RISC score. No genetic interaction between SERT promoter VNTR and DAT1 3'-UTR VNTR with CD-RISC score was detected.CONCLUSIONS:
Either serotonin or dopamine transporter did not seem to play a significant role for psychological resilience in this sample.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychology
/
Dopamine
/
Serotonin
/
Tandem Repeat Sequences
/
Dopamine Plasma Membrane Transport Proteins
/
Serotonin Plasma Membrane Transport Proteins
/
Resilience, Psychological
/
Genetic Background
/
Genotype
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS