Relationship between Serum Inflammatory Marker and Psychotic Symptoms in Inpatients with Schizophrenia or Schizoaffective Disorder
Journal of the Korean Society of Biological Psychiatry
;
: 193-198, 2012.
Article
in Korean
| WPRIM
| ID: wpr-725250
ABSTRACT
OBJECTIVES:
Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia.METHODS:
Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS).RESULTS:
In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP < or = 0.3 mg/dL (normal CRP group, n = 12).CONCLUSIONS:
Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychopathology
/
Psychotic Disorders
/
Schizophrenia
/
C-Reactive Protein
/
Inpatients
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2012
Type:
Article
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