Association Analysis of Polymorphisms on Dystrobrevin Binding Protein 1 (DTNBP1) Gene with Schizophrenia in the Korean Population
Journal of the Korean Society of Biological Psychiatry
;
: 149-158, 2009.
Article
in Korean
| WPRIM
| ID: wpr-725284
ABSTRACT
OBJECTIVES:
This study was designed to investigate the association of schizophrenia and P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene in Korean patients.METHODS:
We analyzed P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene from their DNAs extracted from their blood in 388 Korean schizophrenic patients (male 198, female 190) and 372 control subjects(male 247, female 125). We compared the differences of genotype and allele distributions of the six polymorphisms on DTNBP1 gene between the Korean schizophrenic patient group and the normal control group.RESULTS:
There were no statistically significant differences of genotype and allele distributions of the P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene between the schizophrenic patient group and the normal control group.CONCLUSION:
The results of this study suggest that P1320, P1325, P1635, P1655, P1763 and SNP A polymorphism on DTNBP1 gene do not have influence on the risk of the schizophnenic in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
DNA
/
Carrier Proteins
/
Dystrophin-Associated Proteins
/
Alleles
/
Genotype
Limits:
Female
/
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2009
Type:
Article
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