Current Understanding in Neurobiology of Depressive Disorders: Imaging Genetic Studies on Serotonin Transporter
Journal of the Korean Society of Biological Psychiatry
;
: 176-180, 2011.
Article
in Korean
| WPRIM
| ID: wpr-725331
ABSTRACT
Depressive disorders have strong genetic components. However, conventional linkage and association studies have not yielded definitive results. These might be due to the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. Imaging genetics explores the influences of genetic variation on the brain function or structure. This technique could provide a more sensitive assessment than traditional behavioral measures in psychiatric studies. Imaging genetics is a relatively new field of psychiatric researches, and may improve our understanding on neurobiology of psychiatric disorders. In this review, current understanding in neurobiology of depressive disorders, especially imaging genetic studies on serotonin transporter will be discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Variation
/
Brain
/
Neurobiology
/
Serotonin
/
Penetrance
/
Depressive Disorder
/
Diagnostic Tests, Routine
/
Serotonin Plasma Membrane Transport Proteins
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2011
Type:
Article
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