Risk Factors for Recurrence in Completely Resected pT1/2N1 Non-small Cell Lung Cancer / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 421-427, 2005.
Article
in Korean
| WPRIM
| ID: wpr-7255
ABSTRACT
BACKGROUND:
Complete surgical resection is the most effective treatment for pT1/2N1 non-small cell lung cancer, however 5 year survival rate of these patients is about 40% and the major cause of death is recurrent disease. We intended to clarify the risk factors of recurrence in completely resected pT1/2N1 non-small cell lung cancer. MATERIAL NADMETHOD:
From Jan. 1990 to Jul. 2003, total of 117 patients were operated for pT1/2N1 non-small cell lung cancer. The risk of recurrence according to patients characteristics, histopathologic findings, type of resection, pattern of lymph node metastasis, postoperative adjuvant treatment were evaluated retrospectively.RESULT:
Mean age of patients was 59.3 years. There were 14 patients with T1N1 and 103 patients with T2N1 disease. Median follow-up time was 27.5 months and overall 5 year survival rate was 41.3%. 5 year freedom-from recurrence rate was 54.1%. Recurrence was observed in 44 (37.6%) patients and distant recurrence developed in 40 patients. 5 year survival rate of patients with recurence was 3.3%, which was significantly lower than patients without recurrence (61.3%, p=0.000). In multi-variate analysis of risk factors for freedom-from recurrence rate, multi-station N1 (hazard ratio=1.997, p=0.047) was a poor prognostic factor.CONCLUSION:
Multi-station N1 is the risk factor for recurrence in completely resected pT1/2N1 non-small cell lung cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Risk Factors
/
Lung Neoplasms
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2005
Type:
Article
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