Effect of Botulinum Toxin A on Capsule Formation in Submuscular Breast Implant Insertion: Rabbit Experimental Model

ABSTRACT

We examined the effects of botulinum toxin after submuscular implant insertion, observing the degree of capsule formation after restricting movement of muscle. 12 female Newzeland white rabbits weighing 2.5~3.0 kg were used in our study. A skin incision 5cm in length was made to above the Latissimus Dorsi muscle followed by a 4cm incision on the muscle. An implant was inserted under the muscle. Botulinum toxin was injected at the right side of the 12 rabbit Latissimus Dorsi muscles (experimental group). Then rabbits were dived in two group, 6 rabbits each. Saline was injected at the left side of the 6 rabbit Latissimus Dorsi muscles (control group) and nothing was given to the others (negative control group). The 12 rabbits were euthanized after 6 months and the capsule surrounding the implant was excised along with adjacent tissue. The thickness of the capsule was taken from 5 locations from the stained tissue and the results were statistically analyzed. There was no statistical significant difference among the groups. Restriction of muscular movement did not have a significant effect in the formation of capsule formation.