Immunocytochemical Assay of Cathepsin D in Fine Needle Aspiration Cytology of Breast Carcinoma and Benign Breast Diseases / 대한세포병리학회지
Korean Journal of Cytopathology
;
: 75-81, 2000.
Article
in Korean
| WPRIM
| ID: wpr-726123
ABSTRACT
Cathepsin D is a protease which is known to facilitate invasion and metastasis of breast carcinoma. Overexpression of cathepsin D is associated with poor clinical outcome and biologic aggressiveness of the breast cancer. We underwent immunocytochemical assay(ICA) for cathepsin D in fine needle aspiration cytology(FNAC) specimens from the breast carcinoma and benign breast diseases. In FNAC specimens cathepsin D was expressed in 21(42.9%) out of 49 cases of invasive ductal carcinoma, whereas negative result was observed in all 15 cases of benign breast diseases including 7 fibroadenomas, 6 fibrocystic diseases, and 2 benign ductal hyperplasias. Among the 11 FNAC specimens from ductal carcinoma in situ(DCIS), cathepsin D was expressed in 3 cases(27.3%). In FNAC specimens immunocytochemistry for cathepsin D showed positive result in 24 out of 60 carcinomas(sensitivity, 40%) and negative result in 15 out of all 15 benign breast diseases(specificity, 100%). No significant correlation was noted between cathepsin D expression in FNAC specimen and clinicohistological characteristics of the breast carcinoma, such as hormone receptors and cell differentiation. In conclusion, ICA of cathepsin D in FNAC specimens thought to be a good adjunct to differentiate malignancy from benign breast diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Diseases
/
Breast Neoplasms
/
Immunohistochemistry
/
Cathepsins
/
Cell Differentiation
/
Cathepsin D
/
Fibroadenoma
/
Carcinoma, Ductal
/
Biopsy, Fine-Needle
Language:
Korean
Journal:
Korean Journal of Cytopathology
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS