Pleiotropic Effects of an Incretin Hormone / 임상당뇨병
Journal of Korean Diabetes
;
: 120-124, 2013.
Article
in Korean
| WPRIM
| ID: wpr-726956
ABSTRACT
The incretin hormones glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have recently received much attention for their roles in type 2 diabetes therapy. GLP-1 stimulated insulin secretion in a glucose-dependent manner and is secreted by intestinal L cells. It also regulates blood glucose concentration, stomach motility, appetite, and body weight. These actions are mediated through G-protein-coupled receptors highly expressed on pancreatic beta cells and also exert indirect metabolic actions. Activation of GLP-1 receptors also produces nonglycemic effects in various tissues. The pleiotropic effects of GLP-1 have been recently reported. The mechanisms identified in preclinical studies have potential translational relevance for the treatment of disease. Here, the nonglycemic effects of GLP-1, especially those on the liver, central nervous system, and bone, were reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appetite
/
Stomach
/
Blood Glucose
/
Body Weight
/
Glucagon
/
Central Nervous System
/
Enteroendocrine Cells
/
Receptors, G-Protein-Coupled
/
Insulin-Secreting Cells
/
Glucagon-Like Peptide 1
Type of study:
Prognostic study
Language:
Korean
Journal:
Journal of Korean Diabetes
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS