Glycemic Targets for the Critically Ill Patient / 임상당뇨병
Journal of Korean Diabetes
;
: 18-24, 2015.
Article
in Korean
| WPRIM
| ID: wpr-726988
ABSTRACT
Critically ill patients often experience hyperglycemia, which may be associated with increased morbidity and mortality. In 2001, van den Berghe et al. suggested significant benefit of normalization of blood glucose level in critically ill patients using intensive intravenous insulin therapy. Subsequent multicenter randomized studies, however, demonstrated adverse effects of tight glucose control. Therefore, while the need for glucose control in critically ill patients is generally accepted, the treatment thresholds for initiation of insulin therapy or target glucose values are still undetermined. Furthermore, occurrence of a hypoglycemic event during intensive insulin therapy is known to be an independent predictor of clinical outcome, and glycemic variability is an important variable of glucose management in the critically ill patients. Novel technological approaches such as a continuous glucose monitoring system (CGMS) might help to overcome some problems of tight glucose control by reducing the risk of hypoglycemia and minimizing glycemic variability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Glucose
/
Mortality
/
Critical Illness
/
Glucose
/
Hyperglycemia
/
Hypoglycemia
/
Insulin
/
Intensive Care Units
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Diabetes
Year:
2015
Type:
Article
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