Regulation of DREAM Expression by Group I mGluR
The Korean Journal of Physiology and Pharmacology
;
: 95-100, 2011.
Article
in English
| WPRIM
| ID: wpr-727372
ABSTRACT
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dynorphins
/
Potassium Channels
/
Proteins
/
Up-Regulation
/
Calcium
/
Receptors, Metabotropic Glutamate
/
Cytoplasm
/
Presenilins
/
Methoxyhydroxyphenylglycol
/
Neurons
Type of study:
Prognostic study
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2011
Type:
Article
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