Can Serum PSA Predict Prostate Volume in Men with Benign Prostatic Hyperplasia? / 대한비뇨기과학회지
Korean Journal of Urology
;
: 574-578, 2005.
Article
in Korean
| WPRIM
| ID: wpr-7274
ABSTRACT
PURPOSE:
To analyze the ability of serum prostate specific antigen (s-PSA) to predict the prostate volume by characterizing the relationship between the prostate volume and serum PSA in men with benign prostate hyperplasia. MATERIALS ANDMETHODS:
We evaluated 1,254 patients, with lower urinary tract symptoms, who had visited our hospital between Jan. 2002 and Aug. 2004. All patients with prostate cancer, prostatitis, and a history of prostatic surgery and alpha-blocker or 5-alpha reductase inhibitor medication were excluded from the study. The baseline s-PSA and prostate volume were determined using standard techniques. Pearson's correlation coefficient was used to analyze the relationship between the s-PSA and prostate volume, and a linear regression model to estimate the prostate volume. Receiver operating characteristics (ROC) curves were constructed to evaluate the ability of the s-PSA to predict cut-off values for assessing prostate enlargement.RESULTS:
The analyses included 959 patients, with mean age, baseline s-PSA and prostate volume of 68.2 years, 3.4ng/ml and 34.4ml, respectively. The s-PSA and prostate volume increased with age. The prostate volume correlated positively with s-PSA (r=0.292, p30ml and 2.0ng/ml to detect a prostate volume>40ml.CONCLUSIONS:
The prostate volume is strongly related to the s-PSA and age in men with benign prostatic hyperplasia (BPH). Since treatment outcomes and the risk of long-term complications depend on the prostate volume, the serum PSA may sufficiently estimate prostate enlargement to be useful in therapeutic decision making in men with BPH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Prostatitis
/
Linear Models
/
ROC Curve
/
Age Factors
/
Prostate-Specific Antigen
/
Decision Making
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2005
Type:
Article
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