Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase
The Korean Journal of Physiology and Pharmacology
;
: 431-436, 2009.
Article
in English
| WPRIM
| ID: wpr-727461
ABSTRACT
The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Catalase
/
Down-Regulation
/
Up-Regulation
/
Cell Death
/
Superoxides
/
Endothelial Cells
/
Hydrogen Peroxide
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2009
Type:
Article
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