3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-kappaB Activation in BV2 Microglial Cells
The Korean Journal of Physiology and Pharmacology
;
: 107-112, 2012.
Article
in English
| WPRIM
| ID: wpr-727551
ABSTRACT
Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as neuronal protection against excitotoxicity and anti-inflammatory property, the biological activity of 3,4,5-trihydroxycinnamic acid (THC), a derivative of hydroxycinnamic acids, has not been clearly examined. The objective of the present study is to evaluate the anti-inflammatory effects of THC on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. THC significantly suppressed LPS-induced excessive production of nitric oxide (NO) and expression of iNOS, which is responsible for the production of iNOS. THC also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1beta and TNF-alpha in BV2 microgilal cells. Furthermore, THC significantly suppressed LPS-induced degradation of IkappaB, which retains NF-kappaB in the cytoplasm. Therefore, THC attenuated nuclear translocation of NF-kappaB, a major pro-inflammatory transcription factor. Taken together, the present study for the first time demonstrates that THC exhibits anti-inflammatory activity through the suppression of NF-kappaB transcriptional activation in LPS-stimulated BV2 microglial cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dronabinol
/
Transcription Factors
/
Caffeic Acids
/
Transcriptional Activation
/
Cytokines
/
NF-kappa B
/
Tumor Necrosis Factor-alpha
/
Coumaric Acids
/
Cytoplasm
/
Neurons
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2012
Type:
Article
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