Lipidomic analysis of plasma lipids composition changes in septic mice
The Korean Journal of Physiology and Pharmacology
;
: 399-408, 2018.
Article
in English
| WPRIM
| ID: wpr-727579
ABSTRACT
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE], phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride [TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritonitis
/
Phosphatidic Acids
/
Phosphatidylcholines
/
Phosphatidylinositols
/
Plasma
/
Lysophosphatidylcholines
/
Biomarkers
/
Punctures
/
Sepsis
/
Ligation
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2018
Type:
Article
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