Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse
The Korean Journal of Physiology and Pharmacology
;
: 33-39, 2014.
Article
in English
| WPRIM
| ID: wpr-727598
ABSTRACT
Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd's purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1beta [IL-1beta], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti-inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 microg/ml for VRE and 1,000 microg/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asia
/
Bacillus anthracis
/
Dinoprostone
/
Cytokines
/
Interleukin-6
/
Nitric Oxide Synthase
/
Capsella
/
Functional Food
/
Cyclooxygenase 2
/
Food, Organic
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2014
Type:
Article
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