Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis
The Korean Journal of Parasitology
; : 719-724, 2016.
Article
in En
| WPRIM
| ID: wpr-72762
Responsible library:
WPRO
ABSTRACT
The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×104 sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aging
/
Acute-Phase Proteins
/
Cytokines
/
Interleukin-4
/
Interleukin-6
/
Coccidiosis
/
Oocysts
/
Immunity, Innate
/
Inflammation
Limits:
Animals
Language:
En
Journal:
The Korean Journal of Parasitology
Year:
2016
Type:
Article