Expression of natriuretic peptide mRNAs in isoproterenol-induced cardiac hypertrophy in rats
The Korean Journal of Physiology and Pharmacology
;
: 235-241, 2000.
Article
in English
| WPRIM
| ID: wpr-727734
ABSTRACT
We examined the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs upon isoproterenol (Iso)-induced cardiac hypertrophy in rats. Then, we tried to investigate the effects of sympatholytics to see if they can modulate the expression of ANP and BNP. In this study, RT-PCR technique was used to characterize the expression of ANP and BNP in right atrium (RA) and left ventricle (LV) of the hypertrophied rat heart. Histologic findings indicated that stimulation of beta-adrenoceptors with Iso for 5 days was sufficient to induce cardiac hypertrophy in rats. A continuous stimulation with Iso for 7 days resulted in an increase of the ANP and BNP expression in the LV and BNP expression in the RA. The increased expressions of ANP and BNP in the LV were slightly inhibited, and the increased expressions of BNP in the RA were markedly inhibited by a continuous treatment with propranolol, metoprolol, and clonidine for 7 days. Overall, our data present a differential expression of the natriuretic peptides in Iso-induced cardiac hypertrophy, and that the mechanisms involved in this differential ANP and BNP gene expression could be mediated via sympathetic nervous system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propranolol
/
Sympathetic Nervous System
/
Sympatholytics
/
RNA, Messenger
/
Gene Expression
/
Clonidine
/
Atrial Natriuretic Factor
/
Cardiomegaly
/
Natriuretic Peptide, Brain
/
Natriuretic Peptides
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2000
Type:
Article
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