Your browser doesn't support javascript.
loading
Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L
The Korean Journal of Physiology and Pharmacology ; : 21-27, 2015.
Article in English | WPRIM | ID: wpr-727830
ABSTRACT
The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1beta , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0+/-3.2%), similar to alpha-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetone / Pharmaceutical Preparations / Water / Dinoprostone / Stomatognathic Diseases / Interleukin-6 / Fusobacterium nucleatum / Aggregatibacter actinomycetemcomitans / Prevotella intermedia / Alpha-Tocopherol Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2015 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetone / Pharmaceutical Preparations / Water / Dinoprostone / Stomatognathic Diseases / Interleukin-6 / Fusobacterium nucleatum / Aggregatibacter actinomycetemcomitans / Prevotella intermedia / Alpha-Tocopherol Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2015 Type: Article