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Activation of Vestibular Neurons Projecting to Autonomic Brain Stem Nuclei Following Acute Hypotension in Rats
The Korean Journal of Physiology and Pharmacology ; : 181-185, 2004.
Article in English | WPRIM | ID: wpr-727926
ABSTRACT
Extracellular regulated protein kinase1/2 (pERK1/2) is one of the major regulatory factors for transcription of the c-fos oncogene in neurons. The purpose of this study was to evaluate the expression of phosphorylated ERK1/2 within the vestibular nuclei (VN) of rats following acute arterial hypotension. Following the acute arterial hypotension induced by rapid hemorrhage, a significant number of pERK1/2-immunoreactive neurons appeared bilaterally in the caudal aspect of the medial and inferior VN. No labeling of pERK1/2 was observed in the lateral VN. The peak expression of pERK1/2 in these nuclei occurred within 5 min after hemorrhage. However, in bilaterally labyrinthectomized rats, the appearance of pERK1/2-immunoreactive neurons was eliminated in the VN. Western blot confirmed the effect of bilateral labyrinthectomy on pERK1/2 protein expression in the medial vestibular nucleus 5 min after hemorrhage. These results suggest that, following acute hypotension, afferent signals from the peripheral vestibular receptors are required for activation of ERK 1/2 in the VN.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oncogenes / Brain / Brain Stem / Vestibular Nuclei / Blotting, Western / Hemorrhage / Hypotension / Neurons Limits: Animals Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oncogenes / Brain / Brain Stem / Vestibular Nuclei / Blotting, Western / Hemorrhage / Hypotension / Neurons Limits: Animals Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2004 Type: Article