The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function
The Korean Journal of Physiology and Pharmacology
;
: 173-179, 2004.
Article
in English
| WPRIM
| ID: wpr-727927
ABSTRACT
Amyloid beta-peptide (A beta) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against A beta -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated A beta-induced apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Amyloid beta-Peptides
/
Apoptosis
/
Cognition
/
Alzheimer Disease
/
Amyloid
/
Learning
/
Memory
/
Neurons
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2004
Type:
Article
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