Morroniside on anti-inflammation activities in rats following acute myocardial infarction
The Korean Journal of Physiology and Pharmacology
;
: 17-21, 2018.
Article
in English
| WPRIM
| ID: wpr-727942
ABSTRACT
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chloral Hydrate
/
Blotting, Western
/
Interleukin-6
/
Neuroprotective Agents
/
Coronary Vessels
/
Troponin T
/
Inflammation
/
L-Lactate Dehydrogenase
/
Myocardial Infarction
/
Myocardium
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2018
Type:
Article
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