A Case of Immunoglobulin G4-related Interstitial Nephritis with Bicytopenia
Journal of Rheumatic Diseases
;
: 401-404, 2015.
Article
in Korean
| WPRIM
| ID: wpr-72802
ABSTRACT
Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory disease found in many organs including biliary tract, salivary gland, kidney, and lung. Tubulointerstitial nephritis is the most common renal manifestation, but hematologic involvement of IgG4-RD is rare. Here, we report on a case of a 57-year-old male with IgG4-related interstitial nephritis with bicytopenia, which was initially thought to be systemic lupus erythematosus. He presented with proteinuria, anemia, thrombocytopenia, and low complement levels. Histological findings showed an increased number of IgG4-positive plasma cells (>200/high power field), and an elevated IgG4/IgG ratio (>90%). Serum levels of IgG and IgG4 were also increased. This case emphasized the importance of differential diagnosis of IgG4-RD and immune complex glomerulonephritis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma Cells
/
Proteinuria
/
Salivary Glands
/
Thrombocytopenia
/
Biliary Tract
/
Complement System Proteins
/
Immunoglobulin G
/
Immunoglobulins
/
Diagnosis, Differential
/
Glomerulonephritis
Type of study:
Diagnostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of Rheumatic Diseases
Year:
2015
Type:
Article
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