Gradual reperfusion lowers the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia
The Korean Journal of Physiology and Pharmacology
;
: 47-52, 1999.
Article
in English
| WPRIM
| ID: wpr-728034
ABSTRACT
Blood flow restoration to ischemic zone of the heart is essential to salvage of ischemic tissue. However, there is a large body of evidence documenting that the reperfusion can induce reperfusion injury like reperfusion-induced malignant arrhythmias. In the present study, employing a cat model of regional cardiac ischemia, we examined if reperfusion rendered in a gradual fashion could lower the incidence of reperfusion-induced ventricular fibrillation (VF), which usually precipitated within a few to several tens of seconds after abrupt reperfusion. The experiments were conducted with male mongrel cats (n=46, 2.5-5 kg). The animals in the control and 30 MIN groups were subjected to an episode of 20- and 30-min left anterior descending coronary artery occlusion, respectively, followed by abrupt reperfusion. The animals in 5 G and 10 G groups received gradual reperfusion over a 5- and 10-min period, respectively, following a 20-min occlusion. The proportion of animals that exhibited VF during the reperfusion phase was 11/15 in the control, 7/10 in the 30 MIN, 5/10 in the 5 G and 2/11 in the 10 G groups. The incidence of VF in the 10 G group was significantly lower than that in the control or 30 MIN group subjected to abrupt reperfusion. These results suggest that the gradual reperfusion is a useful procedure against reperfusion-induced VF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Ventricular Fibrillation
/
Reperfusion
/
Reperfusion Injury
/
Transcutaneous Electric Nerve Stimulation
/
Incidence
/
Coronary Vessels
/
Heart
/
Ischemia
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
1999
Type:
Article
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