Amperozide decreases cocaine-induced increase in behavior and immediate early gene expression in the dorsal striatum
The Korean Journal of Physiology and Pharmacology
;
: 361-367, 2000.
Article
in English
| WPRIM
| ID: wpr-728141
ABSTRACT
Cocaine functions as indirect dopamine and serotonin (5-hydroxytryptamine, 5HT) agonists and induces genomic and behavioral alterations in the striatum. Previously we demonstrated that ritanserin, a 5HT2/1C receptor antagonist, is not responsible for cocaine-induced behavioral alterations and zif268 mRNA gene expression in the striatum (see the previous paper in this issue). In this study, it was hypothesized that dopamine and 5HT2/1C receptors are required for cocaine-induced behavioral alterations and c-fos and zif268 mRNA expression. This hypothesis was addressed by infusing amperozide which antagonizes both 5HT2/1C and dopamine receptors and was analyzed using the quantitative in situ hybridization histochemistry in vivo. Systemic injection of amperozide (5 mg/kg, s.c.) significantly blocked increase in behavior, c-fos and zif268 mRNA expression induced by 15 mg/kg cocaine, i.p., in the dorsal striatum. These data suggest that dopamine and 5HT2/1C receptors are necessary for cocaine-induced behavioral alterations and immediate early gene expression in the dorsal striatum.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Dopamine
/
Serotonin
/
Gene Expression
/
Receptors, Dopamine
/
Ritanserin
/
In Situ Hybridization
/
Cocaine
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2000
Type:
Article
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