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Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
Article in English | WPRIM | ID: wpr-728178
Responsible library: WPRO
ABSTRACT
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Permeability / Phosphatidylcholines / Rats / Sodium Dodecyl Sulfate / Naphthoquinones / Deoxycholic Acid / Absorption / Intestinal Absorption / Intestine, Large Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Permeability / Phosphatidylcholines / Rats / Sodium Dodecyl Sulfate / Naphthoquinones / Deoxycholic Acid / Absorption / Intestinal Absorption / Intestine, Large Language: English Journal: The Korean Journal of Physiology and Pharmacology Year: 2013 Type: Article