Selective cytotoxicity of a novel platinum (II) coordination complex on human gastric cancer cell lines and normal kidney cells
The Korean Journal of Physiology and Pharmacology
;
: 283-291, 1999.
Article
in English
| WPRIM
| ID: wpr-728246
ABSTRACT
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of (Pt(cis-DACH)(DPPE)) cntdot 2NO3 (PC) was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant (MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less than those of cisplatin in rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues using MTT assay, (3H)-thymidine uptake and glucose consumption tests. Based on these results, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platinum
/
Stomach Neoplasms
/
Adenocarcinoma
/
Cell Line
/
Cisplatin
/
Glucose
/
Kidney
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
1999
Type:
Article
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