Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels
The Korean Journal of Physiology and Pharmacology
; : 327-332, 2012.
Article
in En
| WPRIM
| ID: wpr-728301
Responsible library:
WPRO
ABSTRACT
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects of sertraline on the major cardiac ion channels expressed in HEK293 cells and the native voltage-gated Ca2+ channels in rat ventricular myocytes. According to the results, sertraline is a potent blocker of cardiac K+ channels, such as hERG, IKs and IK1. The rank order of inhibitory potency was hERG >IK1> IKs with IC50 values of 0.7, 10.5, and 15.2 microM, respectively. In addition to K+ channels, sertraline also inhibited INa and ICa, and the IC50 values are 6.1 and 2.6 microM, respectively. Modification of these ion channels by sertraline could induce changes of the cardiac action potential duration and QT interval, and might result in cardiac arrhythmia.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Arrhythmias, Cardiac
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Action Potentials
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Selective Serotonin Reuptake Inhibitors
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Sertraline
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Inhibitory Concentration 50
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Muscle Cells
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HEK293 Cells
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Ion Channels
Limits:
Animals
Language:
En
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2012
Type:
Article