Effects of analgesics and antidepressants on TREK-2 and TRESK currents
The Korean Journal of Physiology and Pharmacology
;
: 379-385, 2016.
Article
in English
| WPRIM
| ID: wpr-728434
ABSTRACT
TWIK-related K+ channel-2 (TREK-2) and TWIK-related spinal cord K+ (TRESK) channel are members of two-pore domain K+ channel family. They are well expressed and help to set the resting membrane potential in sensory neurons. Modulation of TREK-2 and TRESK channels are involved in the pathogenesis of pain, and specifi c activators of TREK-2 and TRESK may be benefi cial for the treatment of pain symptoms. However, the effect of commonly used analgesics on TREK-2 and TRESK channels are not known. Here, we investigated the effect of analgesics on TREK-2 and TRESK channels. The effects of analgesics were examined in HEK cells transfected with TREK-2 or TRESK. Amitriptyline, citalopram, escitalopram, and fluoxetine significantly inhibited TREK-2 and TRESK currents in HEK cells (p<0.05, n=10). Acetaminophen, ibuprofen, nabumetone, and bupropion inhibited TRESK, but had no effect on TREK-2. These results show that all analgesics tested in this study inhibit TRESK activity. Further study is needed to identify the mechanisms by which the analgesics modulate TREK-2 and TRESK differently.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sensory Receptor Cells
/
Spinal Cord
/
Citalopram
/
Ibuprofen
/
Fluoxetine
/
Bupropion
/
Potassium Channels, Tandem Pore Domain
/
Amitriptyline
/
Analgesics
/
Acetaminophen
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2016
Type:
Article
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