Insulin resistance and apolipoprotein B as a metabolic syndrome risk factor in normal glucose tolerance / 대한내과학회지

ABSTRACT

BACKGROUND: Insulin resistance is associated with greatly increased risk of coronary artery disease. Serum apolipoprotein B and the ratio of apo A-1/Apo B are important markers of the coronary artery disease. The aim of this study was to assess the association of serum apolipoprotein B and the ratio of apo A-1/Apo B with insulin resistance in normal glucose tolerance. METHODS: From individual, who participated in medical screening at health promotion center in Kangbuk Samsung Hospital from Jan. to Dec. 2002, total 7427 participants (4356 men, 3071 women) were enrolled in this study. All participants was no personal history of diabetes and normal fasting glucose. We assess the clinical characteristics and biochemical parameters of subjects. RESULTS: Apolipoprotein B, total cholesterol/HDL-C and LDL-C/HDL-C show an positive correlation with metabolic syndrome and insulin resistance (p<0.001). Apo A-I, Apo A-I/Apo B, LDL/Apo B and HDL/Apo A-I show an negative correlation with metabolic syndrome and insulin resistance (p<0.001). CONCLUSION: These data suggest that insulin resistance are associated with serum apolipoprotein B and the ratio of apo A-1/Apo B in normal glucose tolerance. And early diagnosis and tight control of insulin resistance in normal glucose tolerance should be administered for the prevention of coronary artery disease.