Identification of Differentially Expressed Genes in Murine Hippocampus by Modulation of Nitric Oxide in Kainic Acid-induced Neurotoxic Animal Model
The Korean Journal of Physiology and Pharmacology
;
: 149-154, 2007.
Article
in English
| WPRIM
| ID: wpr-728473
ABSTRACT
Kainic acid (KA) causes neurodegeneration, but no consensus has been reached concerning its mechanism. Nitric oxide may be a regulator of the mechanism. We identified differentially expressed genes in the hippocampus of mice treated with kainic acid, together with or without L-NAME, a nonselective nitric oxide synthase inhibitor, using a new differential display PCR method based on annealing control primers. Eight genes were identified, including clathrin light polypeptide, TATA element modulatory factor 1, neurexin III, ND4, ATPase, H+ transporting, V1 subunit E isoform 1, and N-myc downstream regulated gene 2. Although the functions of these genes and their products remain to be determined, their identification provides insight into the molecular mechanism(s) involved in KA-induced neuronal cell death in the hippocampal CA3 area.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymerase Chain Reaction
/
Clathrin
/
Cell Death
/
Proton-Translocating ATPases
/
Nitric Oxide Synthase
/
NG-Nitroarginine Methyl Ester
/
Models, Animal
/
Consensus
/
Hippocampus
/
Kainic Acid
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2007
Type:
Article
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